GutPro® Infant Probiotic Powder by Organic 3
- Contains 7 clinically-proven strains of human probiotics (B. infantis, B. bifidum, B. breve, B. longum, B. lactis, L. gasseri, L. salivarius).
- Is 50% Bifidobacterium infantis.
- Gives you 6+ Billion CFUs per 1/64 teaspoon (The "drop" on our spoon set. We recommend first-time buyers purchase our GutPro® Powder measuring spoons).
- Is formulated specifically for young children and infants' developing gut ecology. It can be used by adults as well.
- Is appropriate for diets including GAPS, SIBO, Body Ecology, autism/PDD-NOS, PANDA/PANS, Paleo, AIP, Ketogenic, gluten-free, soy-free and casein-free (Please note: While GutPro® was designed based on feedback from these specific communities, we do not imply that it's intended to treat a specific medical condition, nor do we imply it's "compliant" with a specific diet).
- Contains only histamine-neutral or histamine-degrading strains of probiotic bacteria.
- Does not contain any strains that produce d-lactate.
- Does not contain streptococcus thermophilus or other strains linked to irritation.
- Does not contain any spore-forming strains of probiotics (e.g. soil bacteria).
- Is free of inulin and other prebiotics.
- Is free of excipients and other added ingredients, i.e. magnesium stearate, silica, titanium dioxide.
- Is free of common allergens. All strains are grown on a dairy-free, soy-free, non-GMO vegetarian culture. Does not contain milk/casein, eggs, fish, shellfish, wheat/gluten, peanuts, tree nuts, yeast, corn or soy.
- Is easy to calibrate the right dose for your child's needs.
- Is American Type Culture Collection (ATCC) certified and freeze-dried at collection to ensure potency.
- Requires refrigeration.
A few more quick notes:
- Please consult with a qualified healthcare practitioner as to whether a probiotic is appropriate for your baby and when to start a regimen.
- You don't need to use much GutPro® Infant. It's a concentrated, high-quality formula. Most of our customers start out by giving their baby only a tiny pinch (a pencil point of powder).
- For a formulation that includes Lactobacillus plantarum, please try GutPro® Powder.
- For a formulation that includes six additional Lactobacillus strains, please try Primal Gut™ Powder.
GutPro® Infant is formulated specifically to help your baby develop a healthy gut ecosystem
It's not easy to see this when babies are first born, but the most important factor in their health is deep inside their digestive systems.
The bacteria that colonize your infant's digestive system impacts his or her health health in numerous ways:
- Gut bacteria make it possible for your baby to digest your breastmilk effectively and gain the full nutritional benefits.1
- The first bacteria to colonize your baby's digestive system can impact how your baby's digestive system develops. Healthy bacteria help your baby develop a sophisticated and strong inner intestinal lining.2
- Probiotic bacteria can help your baby weather the transition to life outside the womb by helping their immune system develop into a protective and well-regulated force.3
- Research on infant microbiomes and brain development reveals that a healthy gut ecosystem is critical for the development of a sharp, limber brain.4
Helping your baby establish a healthy colony of probiotic bacteria may be one of the best things you can do for his or her future health.
Often, this ecosystem is established simply by exposure to healthy bacteria in the mother's birth canal and breastmilk. But with the rise of C-sections, vaccines, breastfeeding issues and the challenges many mothers face with their own digestive health, many babies begin with a deficit when it comes to establishing a well-rounded gut ecology.
For this reason, many moms and dads add an infant probiotic to their children's early feedings.
GutPro® Infant gives your child the most appropriate probiotics for developing intestinal tracts. Just as importantly, we've been careful to exclude probiotic strains that – while beneficial for adults – have been shown to cause problems in sensitive, developing bodies.
And while GutPro® Infant has been formulated with babies in mind, it's also a great mix for children and adults who want a gentle and safe probiotic blend.
GutPro® Infant features Bifidobacterium Infantis, "champion colonizer of the infant gut"
If there's one probiotic bacteria newborn infants need in their guts, it's Bifidobacterium infantis.*
This unique bacteria strain dominates in breastfed babies' intestines. And there's a good reason why. B. infantis has evolved with human breast milk to occupy a unique niche in human gut development. It turns out human breast milk contains some unique oligosaccharides. Incredibly difficult and expensive to produce, these complex molecules make up a full third of breast milk's components.
But here's the funny thing . . .
Human babies can't digest them!
So why do human moms make them?
Well, they're the favorite food of Bifidobacterium infantis. In fact, B. infantis is the only bacteria strain, it seems, that can fully digest these unique oligosaccharides.
Thanks to the presence of these nourishing prebiotics in human breast milk, B. infantis thrives in the newborn's digestive tract.
And in exchange, B. infantis performs an invaluable service . . .
In a cohort study in India, B. infantis was linked to healthy growth and immune response in infants.5 While the study cannot prove causation, additional studies have made a clear link between B. infantis and the healthy development of the baby's immune system and digestive system.*
This is particularly critical for pre-term babies, since digestive problems are common. In no less than five clinical trials (see below) on preterm infants, B. infantis supplementation ensured the babies maintained healthy, functioning digestive tracts.
How does B. infantis do this?
- First, they take over. Simply by multiplying and thriving by feasting on the human milk oligosaccharides, they leave little room for unwanted bacteria. They make sure that the digestive ecosystem is a healthy one.
- Secondly, they seem to help babies develop a well-regulated immune system.* Lab research has demonstrated that these special bacteria "coach" the baby's immune cells to regulate themselves with sophistication. B. infantis' presence in the gut seems to inhibit the production of immune cytokines that signal inflammation.*
- Thirdly, B. infantis seems to help a strong and sturdy intestinal lining develop. Without too many gaps between cells. So the intestines can do their job of selectively allowing nutrients to enter the bloodstream.
- Finally, this bacteria strain seems to promote the production of the short chain fatty acid, acetate, over butyrate. While butyrate is good for adults, some studies have linked overproduction of butyrate to digestive problems in infants. By tipping the balance toward acetate, B. infantis seems to help keep the chemical balance in babies' guts healthy.6
With this long-evolved symbiotic relationship between B. infantis and newborn infants, we made sure B. infantis was in our formulation.
And – taking a hint from Nature – we made sure it was a full 50% of the formula.
But that's not all we've included in this carefully developed formula...
GutPro® Infant also has Bifidobacterium breve
B. breve is also a star in the probiotic world when it comes to children who need extra help with their microbiome.* Found in human breast milk, B. breve can also digest human milk oligosaccharides – but not as thoroughly as B. infantis.
It's considered one of the first colonizers of human intestinal tract. And research shows it can help this colonization happen fast.
The research on the various roles this bacteria plays in keeping your child's gut healthy is extensive:
- B. breve has been linked to helping with childhood constipation.*7
- A few clinical trials involving pre-term babies indicated that this special bacteria works especially well in helping to establish a healthy gut ecology.* 8
- In one of these studies, researchers concluded that B. breve also seems to help these tiny babies gain weight.*9
- Clinical research has also demonstrated that when combined with a gluten-free diet, B. breve can help restore microbial balance in the digestive tract of children who have experienced some intestinal inflammation.*10
As children grow older and face health challenges, B. breve continues to bring strategic support . . .
- Clinical research suggests this special bacterium is particularly effective in re-colonizing the gut of children who have undergone chemotherapy.*11 The children who took this probiotic seemed to recover better from the treatment without any complications that are usually associated with chemotherapy.
B. breve is clearly a powerful ally for B. infantis in helping your baby start off with a healthy digestive system. These two lay the foundation for an effective probiotic team.
But we didn't stop there . . .
Contains five additional probiotics proven to keep children healthy
In consultation with parents and health practitioners, we've added five additional probiotic superstars. Each of these strains has been shown to be safe and beneficial for children and infants.
Bifidobacterium longum - One of the first bacteria to colonize our bodies at birth, B. longum has been associated with helping to digest milk and other challenging foods. *12 A placebo-controlled clinical study on 33 children with some digestive discomfort showed that in combination with a gluten-free diet, B. longum not only helped them grow taller, but also showed some indications of keeping their immune system strong and balanced.13
Bifidobacterium lactis - In one eye-opening study, when pre-term babies were given Bifidobacterium lactis after taking antibiotics, they gained an amazing four times as much weight as the babies given the placebo.* And interestingly, these babies gained more weight even though they consumed less milk! In this same study, researchers observed signs that B. lactis helped the babies' immune systems develop effectively.*14
A meta-analysis of five studies revealed that B. lactis' role in supporting healthy weight gain may be particularly effective in the most vulnerable babies. Researchers looking at the data found that this bacterium seemed to help babies born to HIV positive moms gain much more weight per day than their counterparts who were not supplementing with a probiotic.*15
Finally – and significantly – preliminary lab research indicates B. lactis shows exciting promise in neutralizing certain toxins from wheat. *16
Bifidobacterium bifidum – In one small study, B. bifidum was the second most common bacteria in infants' guts (B. infantis was first).17 And for good reason . . . It seems to help keep the immune system strong and help the digestive system stay right on track.*
A 2015 clinical study published in the British Journal of Nutrition showed B. bifidum helped academically stressed college students make it through the winter semester. The students who took B. bifidum had much fewer absences than the students who didn't take the probiotic.18 Another clinical study indicates B. bifidum may help with abdominal discomfort, gas and bloating.*19 And a recent randomized placebo-controlled study also showed that B. bifidum can help with stress-related diarrhea.*20
Lactobacillus salivarius - Several clinical trials on both adults and children indicate that l. salivarius seems to help regulate the immune system and - as a result- support healthy skin.*21 L. salivarius also seems to play a distinct role in keeping the microbial population in your mouth healthy.*22
Lactobacillus gasseri - A clinical trial on children with L. gasseri published in the European journal, Pediatric Allergy And Immunology showed that this bacterium seemed to help regulate the immune system*. Children who took L. gasseri showed an increase in regulatory T cell counts and a decrease in immunoglobulin E.23Preliminary research on mice indicates that L. gasseri may inhibit inflammation signaling at the genetic level!24
You can see all the good strains we've included in this mix to help your baby get the right start, or to help your older children stay on track.
But it's not just what we've put in this mix that counts. It's also what we've left out!
Does not contain strains linked to d-lactate acidosis
Lactobacillus acidophilus can work wonders in the gut by producing lactic acid. It also can cause problems.
Lactate is a derivative of lactic acid. It comes in two isomeric forms, d-lactate and l-lactate. Most of us have the capacity to metabolize both forms to some extent and turn it into pyruvic acid.
But for various reasons, some people can't metabolize d-lactate effectively enough to keep up the d-lactate produced by gut bacteria. As a result, the d-lactate can build up in your body and cause d-lactate acidosis.25
To date, d-lactate acidosis has not been widely documented as a common problem in infants. However, many health professionals are concerned that it could be an issue with developing digestive tracts. For this reason, we've decided to keep these questionable strains out of our infant formulation.
GutPro® Infant probiotics does not contain any strain linked to d-lactate production or d-lactate acidosis. So you don't have to worry about this becoming a problem for your baby.
But that's not the only problem we've avoided with this formula.
No histamine-producing probiotics
D-lactate producing probiotics aren't the only troublesome strains. Some probiotics, like L. casei, produce histamines. Histamines are chemicals that can trigger an immune response.
Ordinarily, your body breaks these molecules down with special enzymes, primarily diamine oxidase (DAO). However, some people don't produce enough of these enzymes. Or their body produces too many histamines for their enzymes to break down adequately.
Their body then reacts to the build-up of histamines. These reactions can include dizziness, headaches, rashes, congestion and digestive discomfort. When your body has these kinds of reactions, it's called a histamine intolerance.
Most reports of histamine intolerance are in adults. However, an increasing number of parents are identifying this as a problem they're seeing in their children.26 Most of this is anecdotal - there isn't much research documenting this in babies and children. Nonetheless, we decided to make sure this probiotic blend took this emerging problem into account.
So we've made sure that the strains included in this formula are either histamine-neutral or histamine-degrading.
That means you won't have to worry about increasing your children's exposure to histamines when you give them this probiotic formula.
Further, we've kept more irritants out of our formula...
No spore-producing bacteria or streptococcus thermophilus
For people concerned about spore-producing Bacillus bacteria or Streptococcus thermophilus (e.g. soil bacteria), we've made sure to keep these strains out as well.
While the research is still ongoing about the impact these strains have on our systems, we decided to play it safe and keep our formula simple and easy on the most sensitive bodies.
But of course, it's not just the probiotic strains you need to consider. Most probiotics supplements are only 10% to 20% probiotics and 80% to 90% something else.
GutPro® Infant is just probiotics – Nothing else!
We've kept this a pure probiotic formula.
- There are no excipients or fillers like silica or magnesium stearate.
- Nor are there any prebiotics like inulin or FOS.
Breast milk already has its own unique prebiotics. And prebiotics have been added to infant formulas with beneficial effects. But bottom line, we want parents to be able to carefully develop their children's diets according to their unique situations. We'd rather you have the choice to bring prebiotics in or - or not.
And, to ensure this formula works for everyone –
- GutPro® Infant is free if common allergens! Every strain we use is grown on a dairy-free, soy-free, vegetarian, non-GMO culture.
GutPro® Infant by Organic 3 is designed for comfort, as we've eliminated the potential problems associated with other probiotic formulas.
Please keep in mind, this in an ultra pure, concentrated probiotic that is unlike anything you will find at the supermarket, so begin low and slow.
Since you're titrating your own dose, we offer our special spoon set to make it easy for you. Some of our customers start with a tiny bit, or a pencil point of 1/64 of a teaspoon ("drop") on our spoon set! Even at this small amount, you will receive billions of well balanced CFUs.
For more information, please see our dosing instructions.
Be assured that with GutPro® Infant, we've removed the strains and other ingredients that can cause problems.
See what GutPro® Infant can do for your child's health
As you now know, this probiotic supplement has been carefully developed based on research, as well as feedback from parents and health practitioners.
Again, each strain has been carefully selected to help young digestive systems develop a healthy ecosystem. Each strain has an excellent safety record and has been cultured under carefully controlled conditions.
So you can be confident your children are getting only strains that will help them feel great.
Because it's a concentrated mix of pure probiotics, a little goes a long way. Many of our customers give their child only a portion of a "drop" (on the spoon set) of this powder. And because it's a powder, you can calibrate it exactly for the needs of each of your children.
But please keep in mind, probiotics can't work in a vacuum. They only amplify a healthy, real food diet. A junk food diet can't be overcome with even the best probiotic formulation.
On the other hand, when combined with a wholesome diet, GutPro® Infant can help your children enjoy the excellent health you work so hard to help them obtain. And you'll never have to worry about undermining this hard work with the wrong probiotic mix.
1 Jiang T et al. Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. J Dairy Sci. 1996 May;79(5):750-7.
2 Underwood MA et al. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research. 2015;77(0):229-235.
3 Houghteling PD et al. Why is initial bacterial colonization of the intestine important to the infant's and child's health? Journal of pediatric gastroenterology and nutrition. 2015;60(3):294-307.
4 Ginley S. UNC Researchers Link Gut Bacteria To Infant Brain Development. August 6, 2016. Viewed 2/12/17 at http://www.newsobserver.com/news/technology/article94057167.html
5 Huda MN, Lewis ZT, Kalanetra KM, et al. Stool microbiota and vaccine responses of infants. Pediatrics. 2014;134:e362–72
6 Underwood MA et al. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research. 2015;77(0):229-235.
7 Tabbers M et al. Is Bifidobacterium breve effective in the treatment of childhood constipation? Results from a pilot study. Nutrition Journal. 2011;10:19.
8 Quagliariello A, et al. Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study. Nutrients. 2016;8(10):660.
9 Kitajima H et al. Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Archives of Disease in Childhood Fetal and Neonatal Edition. 1997;76(2):F101-F107.
10 Duque Braga TD et al. Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial. Am J Clin Nutr 2011 93: 1 81-86; First published online October 27, 2010.
11 Yamashiro Y et al. Beneficial microbes for premature infants, and children with malignancy undergoing chemotherapy. Benef Microbes. 2010 Nov;1(4):357-65.
12 Perlmutter D et al. Brainmaker. Little, Brown & Company. p. 210
13 Olivares M et al. Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. Br J Nutr. 2014 Jul 14;112(1):30-40. doi: 10.1017/S0007114514000609. Epub 2014 Apr 28.
14 Mohan R et al. Effects of Bifidobacterium lactis Bb12 Supplementation on Body Weight, Fecal pH, Acetate, Lactate, Calprotectin, and IgA in Preterm Infants. Pediatric Research (2008) 64, 418–422.
15 Steenhout PG et al. The effect of Bifidobacterium lactis on the growth of infants: a pooled analysis of randomized controlled studies. Ann Nutr Metab. 2009;55(4):334-40. doi: 10.1159/000248992. Epub 2009 Oct 16.
16 Lindfors K et al. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clinical and Experimental Immunology. 2008;152(3):552-558.
17 Turroni F et al. Diversity of Bifidobacteria within the Infant Gut Microbiota. PLOS One. May 11, 2012
18 Langkamp-Henken B et al.Bifidobacterium bifidum R0071 results in a greater proportion of healthy days and a lower percentage of academically stressed students reporting a day of cold/flu: a randomised, double-blind, placebo-controlled study.
Br J Nutr. 2015 Feb 14;113(3):426-34.Epub 2015 Jan 21.
19 Guglielmetti S et al.. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life: a double-blind, placebo-controlled study. Alimentary Pharmacology and Therapeutics, Wiley, 2011, 33 (10), pp.1123.
20 Culpepper T et al. Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial. Benef Microbes. 2016 Jun;7(3):327-36. doi: 10.3920/BM2015.0156. Epub 2016 Feb 3.
21 Drago L et al. Treatment of atopic dermatitis eczema with a high concentration of Lactobacillus salivarius LS01 associated with an innovative gelling complex: a pilot study on adults.J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S47-51.
22 Haukioja A. Probiotics and Oral Health. European Journal of Dentistry. 2010;4(3):348-355.
23 Martinez-Canavate A et al. A probiotic dairy product containing L. gasseri CECT5714 and L. coryniformis CECT5711 induces immunological changes in children suffering from allergy.Pediatr Allergy Immunol. 2009 Sep;20(6):592-600.Epub 2009 Jul 8.
24 Miyoshi M et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice.Eur J Nutr. 2014;53(2):599-606. doi: 10.1007/s00394-013-0568-9. Epub 2013 Aug 6
25 Higgins C. L-lactate and d-lacate – clinical significance in the difference. Acute Care Testing. October 2011. Viewed 2/10/17 at http://acutecaretesting.org/en/articles/l-lactate-and-d-lactate-clinical-significance-of-the-difference
26 Maintz L et al. Histamine and histamine intolerance. Am J Clin Nutr May 2007. vol. 85 no. 5 1185-1196